Mitochondria and Bioenergetics (Are these the Jedi Mito/Medichlorines?) The real details -- MitoCs in Neurogenerative Diseases, Plant Physiology, Biochemistry, Pathology, Breakdown, Biogenesis (Liver Surgery?, Chloroplasts and Chlamydomonas, and much more ...

This book describes the use of quantitative methods in studies in organized metabolic systems, such as mathematical modeling and Metabolic Control Analysis, for investigation of the problems of bioenergetics of the cell and also presents new experimental results. The following central problems of cellular bioenergetics are the focus of the discussions: the mechanisms of regulation of oxidative phosphorylation in cells in vivo in health and disease, the influence of fine intracellular structural organization on mitochondrial function, the intracellular networks of energy transfer and metabolic feedback signaling, the role of mitochondria in intracellular calcium cycling, and changes in mitochondrial membrane systems and cellular energetics under pathological conditions. Systematic studies from many laboratories presented in this volume convincingly show that many mitochondrial properties, including affinities for mitochondrial creatine kinase and its molecular biology are related to its molecular physiology and functional coupling to adenine nucleotide translocase, as well as its participation, together with the adenylate kinase system, in intracellular energy transfer. The results of the studies of creatine kinase-deficient transgenic mice are summarized and analyzed using mathematical models of the compartmentalized energy transfer, thus combining two powerful new research methods. All these results, together with physiological and NMR data on the cardiac metabolic and mitochondrial responses to workload changes, confirm the concept of metabolic networks of energy transfer and feedback regulation. The papers, mostly review articles, are written by the leading experts in the field who analyze their experience of research and give insights into the future development of this increasingly important area of biological sciences.

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Mitochondria by Immo E. Scheffler

Mitochondria are complex organelles, possessing inner and outer membranes and even their own DNA. A typical cell contains 800 mitochondria, termed the "powerhouse of the cell", playing a central role in metabolism, respiration, and ATP production. Mitochondria is the first modern, truly comprehensive authored book which tackles the biochemistry, genetics, and pathology of mitochondria in different organisms.

Mitochondria and Free Radicals in Neurodegenerative Diseases by M. Flint Beal(Editor)

Comprehensive review of the role of mitochondrial dysfunction and oxidative damage in the pathogenesis of neurodegenerative diseases. Outline format. 26 contributors.

Mitochondria and Cell Death by G. C. Brown(Editor)

This book is a welcome overview of the involvement of mitochondria in cell death and disease, an extraordinarily active research area of major importance to both basic biology and medical science. Clear and thorough chapters present the current approaches leading research teams are taking to examine the role that mitochondria play in inducing the death of various cell types, including heart, brain, and liver cells.

The volume is comprehensive in that it examines apoptosis and necrosis from multiple levels and perspectives. As well as covering the genetic and biochemical basis of mitochondrial involvement in cell death, it details how mitochondrial dysfunction could result in various neurodegenerative, inflammatory, and ischemic diseases, and the aging process. Researchers and postgraduates throughout the biological and medical sciences--particularly those investigating the causes and potential treatments of cancers, septic shock, Parkinson's disease, and Alzheimer's disease--will benefit from this book.

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