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Highly Recommended Resources - Hand Picked to save you valuable searching time.
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- Did you know that " ...the best ways to
visualize Lewy bodies in brain tissue is to use antibodies against ubiquitin,
because they contain high levels of ubiquitinated proteins.
In cells, ubiquitin first binds to proteins displaying degradation signals,
then recruits further ubiquitin molecules to form a poly-ubiquitin chain. This
'flags' the protein for destruction by the 26S proteasome. In
neurodegenerative disease, incompletely degraded, ubiquitinated proteins
accumulate in Lewy bodies."? (Curious about the
Lewy body?" One of the pathological features of most types of
Parkinson's disease is the appearance of an inclusion body, known as a Lewy
body, in many regions of the brain. The Lewy body is associated with
neuronal degeneration, and is also seen in Alzheimer's disease"
--from the ncbi)
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- Ubiquitin
and Disease
- Josep M., FJ Lopez-Soriano, Argiles, J. Pallares-Trujillo / Hardcover /
Published 1998
The book deals with the understanding of the molecular basis of diseases
where defects in ubiquitin gene expression and/or synthesis are involved.
Among these, Alzheimer's and other neurodegenerative diseases, muscle
dystrophies, cancer, muscle wasting and autoimmune diseases.
The importance of the ubiquitin-dependent proteolysis is also studied in
aging and a special emphasis is put in understanding the regulation of this
ATP-dependent proteolytic system in order to design future therapeutic
strategies.
- Ubiquitin
and the Biology of the Cell
- Jan-Michael Peters(Editor), James R. Harris (Editor) / Hardcover /
Published 1998 -- "a comprehensive review of the biology of
ubiquitin from its crystal structure, biochemical function, and role in
normal and abnormal (pathological) cellular mechanisms"
- Cellular
Proteolytic Systems (Modern Cell Biology)
- Aaron J. Ciechanover(Editor), et al / Paperback / Published 1994 --
Provides a detailed and comprehensive summary of advances in the
biochemistry, cellular biology, molecular genetics and physiology of the
major proteolytic processes within the cell. Describes the current
understanding of the three major cellular proteolysis systems: the ubiquitin
system, the lysosomal/vacuolar systems and physiological and
pathophysiological cellular proteolysis.
- Ubiquetin
System (Current Communications in Molecular Biology)
- Milton J Schlesinger / Paperback / Published 1988
- Ubiquitin
- Martin C. Rechsteiner / Hardcover / Published 1988
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